5 Easy Facts About akorn promethazine codeine Described
5 Easy Facts About akorn promethazine codeine Described
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When the response to an opioid antagonist is suboptimal or only temporary in mother nature, administer supplemental antagonist as directed through the solution’s prescribing info. The respiratory depressant consequences of promethazine usually are not reversed by opioid antagonists, such as naloxone.
Respiration troubles (respiratory depression) that can result in death and opioid withdrawal can occur if You begin using or cease having other medicines when using Promethazine Hydrochloride and Codeine Phosphate Oral Option, together with:
Possibility Summary Promethazine HCl and codeine phosphate oral solution is not encouraged for use in Expecting Gals, which includes all through or quickly prior to labor.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced, necessitating mindful thing to consider of the results on the father or mother drug, codeine, plus the Lively metabolite, morphine.
Even so, this effect will not be steady and should be offset by an elevated charge of cervical dilation, which tends to shorten labor. Check neonates exposed to opioids in the course of labor for indications of excessive sedation and respiratory melancholy.
“It may also get some time to ramp up with some of these prescription drugs, so item is probably not currently available, but it may be available within a couple months.”
A residence teaspoon just isn't an precise measuring system and could lead to overdosage [see Warnings and Safety measures (5.7)]. For prescriptions where a measuring machine just isn't supplied, a pharmacist can offer an ideal measuring unit and can offer Guidelines for measuring the correct dose. Do not overfill. Rinse the measuring unit with h2o after each use.
five.8 Routines Demanding Psychological Alertness: Challenges of Driving or Operating Equipment Codeine and promethazine, two of the active ingredients in promethazine HCl and codeine phosphate oral Resolution, may perhaps deliver marked drowsiness and impair the psychological and/or Actual physical qualities demanded for your overall performance of doubtless hazardous jobs for example driving an auto or running machinery.
MAOI Conversation Tell more info sufferers not to acquire promethazine HCl and codeine phosphate oral Resolution although making use of or inside of fourteen days of stopping any medication that inhibit monoamine oxidase.
All facts introduced Here's not intended as a substitute for or substitute to facts from well being care practitioners. Make sure you talk to your overall health care Skilled about probable interactions or other doable troubles prior to utilizing any solution. The Federal Foods, Drug, and Cosmetic Act call for this observe.
We anticipate reposting the photographs at the time we have been capable identify and filter out images that don't match the data delivered from the drug labels. NDC Codes
Labor or Shipping and delivery Opioids cross the placenta and may develop respiratory despair and psycho-physiologic outcomes in neonates. An opioid antagonist, for example naloxone, must be readily available for reversal of opioid-induced respiratory depression in the neonate. Opioids, together with promethazine HCl and codeine phosphate oral Option, can prolong labor through actions which temporarily decrease the toughness, period, and frequency of uterine contractions.
Serotonin Syndrome Advise individuals that promethazine HCl and codeine phosphate oral Remedy could result in a rare but potentially lifetime-threatening situation resulting from concomitant administration of serotonergic medication.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate, necessitating mindful thought of the results within the guardian drug, codeine, plus the active metabolite, morphine.